HKDC1 antibody (N-Term) (HRP)

Catalog No. ABIN7997459

The HRP-conjugated Rabbit Polyclonal anti-HKDC1 antibody (ABIN7997459) specifically detects HKDC1 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for HKDC1 antibody (N-Term) (HRP) (ABIN7997459)

Target: HKDC1 (Hexokinase Domain Containing 1 (HKDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HKDC1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-HKDC1 Antibody (HRP)

Binding Specificity: N-Term

Purpose: Anti-HKDC1 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by four amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human HKDC1, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HKDC1

Target: HKDC1 (Hexokinase Domain Containing 1 (HKDC1))

Alternative Name: HKDC1

Background:

Background: The epidermal growth factor receptor (HKDC1, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). HKDC1 exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). HKDC1 and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to HKDC1 overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of HKDC1, called HKDC1vIII is often observed.

Gene Full Name: hexokinase domain containing 1

Sequence Similarities: Belongs to the hexokinase family.

Gene ID: 80201

UniProt: Q2TB90