HDC antibody (AA 12-662) (PE)

Catalog No. ABIN7997659

The Rabbit Polyclonal anti-HDC antibody is suitable to detect HDC in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for HDC antibody (AA 12-662) (PE) (ABIN7997659)

Target: HDC (Histidine Decarboxylase (HDC))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDC antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-HDC Antibody (PE)

Binding Specificity: AA 12-662

Purpose: Anti-Histidine decarboxylase/HDC Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Histidine decarboxylase/HDC recombinant protein (Position: R12-V662).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HDC

Target: HDC (Histidine Decarboxylase (HDC))

Alternative Name: HDC

Background:

Background: HDC(Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

Gene Full Name: histidine decarboxylase

Gene ID: 3067

UniProt: P19113