HDC antibody (AA 12-662)

Catalog No. ABIN7997661

This Rabbit Polyclonal antibody specifically detects HDC in WB, IHC and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for HDC antibody (AA 12-662) (ABIN7997661)

Target: HDC (Histidine Decarboxylase (HDC))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Grade: Carrier-free

Product Details anti-HDC Antibody

Binding Specificity: AA 12-662

Purpose: Anti-Histidine decarboxylase/HDC Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Histidine decarboxylase/HDC Antibody. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Histidine decarboxylase/HDC recombinant protein (Position: R12-V662).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HDC

Target: HDC (Histidine Decarboxylase (HDC))

Alternative Name: HDC

Background:

Background: HDC(Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

Gene Full Name: histidine decarboxylase

Molecular Weight: 74 kDa

Gene ID: 3067

UniProt: P19113