HDAC11 antibody (N-Term) (Fluoro647)

Catalog No. ABIN7997737

The Rabbit Polyclonal anti-HDAC11 antibody is suitable to detect HDAC11 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for HDAC11 antibody (N-Term) (Fluoro647) (ABIN7997737)

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC11 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-HDAC11 Antibody (Fluoro647)

Binding Specificity: N-Term

Purpose: Anti-HDAC11 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC11, different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Alternative Name: HDAC11

Background:

Background: Histone deacetylase 11 is a 39 kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

Gene Full Name: histone deacetylase 11

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Gene ID: 79885

UniProt: Q96DB2