HTRA2 antibody (AA 30-458) (Fluoro647)

Catalog No. ABIN7998398

The Fluoro647-conjugated Rabbit Polyclonal anti-HTRA2 antibody (ABIN7998398) specifically detects HTRA2 in FACS. The antibody is reactive with Human samples.

Quick Overview for HTRA2 antibody (AA 30-458) (Fluoro647) (ABIN7998398)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-HTRA2 Antibody (Fluoro647)

Binding Specificity: AA 30-458

Purpose: Anti-HTRA2 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human HTRA2 shares 85.7% amino acid (aa) sequence identity with mouse HTRA2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HTRA2 recombinant protein (Position: R30-E458). Human HTRA2 shares 85.7% amino acid (aa) sequence identity with mouse HTRA2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2

Background:

Background: Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene Full Name: HtrA serine peptidase 2

Gene ID: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity