HYAL1 antibody (C-Term) (HRP)

Catalog No. ABIN7998538

The Rabbit Polyclonal anti-HYAL1 antibody is suitable to detect HYAL1 in samples from Mouse. It has been validated for WB, IHC and ELISA.

Quick Overview for HYAL1 antibody (C-Term) (HRP) (ABIN7998538)

Target: HYAL1 (Hyaluronidase-1 (HYAL1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HYAL1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-HYAL1 Antibody (HRP)

Binding Specificity: C-Term

Purpose: Anti-Hyaluronidase-1 HYAL1 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1, different from the related rat sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HYAL1

Target: HYAL1 (Hyaluronidase-1 (HYAL1))

Alternative Name: HYAL1

Background:

Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Gene Full Name: hyaluronoglucosaminidase 1

Sequence Similarities: Belongs to the glycosyl hydrolase 56 family.

Gene ID: 15586

UniProt: Q91ZJ9

Pathways: Glycosaminoglycan Metabolic Process