HMBS antibody (AA 6-361)

Catalog No. ABIN7998674

The Rabbit Polyclonal anti-HMBS antibody (ABIN7998674) specifically detects HMBS in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HMBS antibody (AA 6-361) (ABIN7998674)

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMBS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-HMBS Antibody

Binding Specificity: AA 6-361

Purpose: Anti-HMBS Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-HMBS Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human HMBS recombinant protein (Position: N6-H361).

Isotype: IgG

Application Details

Application Notes: Western blot,0.1-0.5 μg/mL, Human, Mouse, Rat ELISA,0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HMBS

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Alternative Name: HMBS

Background:

Background: Porphobilinogen deaminase (hydroxymethylbilane synthase, or uroporphyrinogen I synthase) is an enzyme that in humans is encoded by the HMBS gene. This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Full Name: hydroxymethylbilane synthase

Molecular Weight: 45 kDa

Gene ID: 3145

UniProt: P08397