HSD17B2 antibody (AA 75-365) (Fluoro550)

Catalog No. ABIN7998799

The Rabbit Polyclonal anti-HSD17B2 antibody is suitable to detect HSD17B2 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for HSD17B2 antibody (AA 75-365) (Fluoro550) (ABIN7998799)

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B2 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-HSD17B2 Antibody (Fluoro550)

Binding Specificity: AA 75-365

Purpose: Anti-HSD17B2 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human HSD17B2 shares 63.6%,65.2% amino acid (aa) sequence identity with mouse,rat HSD17B2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HSD17B2 recombinant protein (Position: Q75-R365). Human HSD17B2 shares 63.6% and 65.2% amino acid (aa) sequence identity with mouse and rat HSD17B2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HSD17B2

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Alternative Name: HSD17B2

Background:

Background: HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42(43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

Gene Full Name: hydroxysteroid 17-beta dehydrogenase 2

Gene ID: 3294

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis