HSD17B6 antibody (C-Term) (Fluoro647)

Catalog No. ABIN7998860

The Fluoro647-conjugated Rabbit Polyclonal anti-HSD17B6 antibody (ABIN7998860) specifically detects HSD17B6 in FACS. The antibody is reactive with Human samples.

Quick Overview for HSD17B6 antibody (C-Term) (Fluoro647) (ABIN7998860)

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B6 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-HSD17B6 Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-HSD17B6 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HSD17B6

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Alternative Name: HSD17B6

Background:

Background: Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action, 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.

Gene Full Name: hydroxysteroid 17-beta dehydrogenase 6

Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Gene ID: 8630

UniProt: O14756

Pathways: Steroid Hormone Biosynthesis