IDS antibody (C-Term) (HRP)

Catalog No. ABIN7999055

The HRP-conjugated Rabbit Polyclonal anti-IDS antibody (ABIN7999055) specifically detects IDS in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for IDS antibody (C-Term) (HRP) (ABIN7999055)

Target: IDS (Iduronate 2-Sulfatase (IDS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDS antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-IDS Antibody (HRP)

Binding Specificity: C-Term

Purpose: Anti-Iduronate 2 sulfatase/IDS Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Iduronate 2 sulfatase.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IDS

Target: IDS (Iduronate 2-Sulfatase (IDS))

Alternative Name: IDS

Background:

Background: IDS (Iduronate-2-sulfatase) is a sulfatase enzyme associated with Hunter syndrome. Iduronate 2-sulfatase is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. Wilson et al. (1991) used an IDS cDNA clone to localize the gene to Xq28, distal to the fragile X site. Faust et al. (1992) and Daniele et al. (1993) demonstrated that the homologous Ids gene in the mouse occupies the same position on the X chromosome in relation to the FMR1, F9, and GABRA3 genes. Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.

Gene Full Name: iduronate 2-sulfatase

Sequence Similarities: Contains 2 follistatin-like domains.

Gene ID: 3423

UniProt: P22304

Pathways: Glycosaminoglycan Metabolic Process