IKZF3 antibody (AA 162-498) (Fluoro488)

Catalog No. ABIN7999128

This Rabbit Polyclonal antibody specifically detects IKZF3 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IKZF3 antibody (AA 162-498) (Fluoro488) (ABIN7999128)

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKZF3 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-IKZF3 Antibody (Fluoro488)

Binding Specificity: AA 162-498

Purpose: Anti-IKZF3 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PARP3 shares 82.2% amino acid (aa) sequence identity with mouse,rat PARP3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PARP3 recombinant protein (Position: Q162-Q498). Human PARP3 shares 82.2% amino acid (aa) sequence identity with mouse and rat PARP3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IKZF3

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Alternative Name: IKZF3

Background:

Background: Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Gene Full Name: IKAROS family zinc finger 3

Gene ID: 22806

UniProt: Q9UKT9