ITPA antibody (AA 1-194) (PE)

Catalog No. ABIN7999641

This Rabbit Polyclonal antibody specifically detects ITPA in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ITPA antibody (AA 1-194) (PE) (ABIN7999641)

Target: ITPA (Inosine Triphosphatase (ITPA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPA antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-ITPA Antibody (PE)

Binding Specificity: AA 1-194

Purpose: Anti-ITPA Antibody PE Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human ITPA shares 89.6%,92.1% amino acid (aa) sequence identity with mouse,rat ITPA,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ITPA recombinant protein (Position: M1-A194). Human ITPA shares 89.6% and 92.1% amino acid (aa) sequence identity with mouse and rat ITPA, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ITPA

Target: ITPA (Inosine Triphosphatase (ITPA))

Alternative Name: ITPA

Background:

Background: Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae, the protein is also encoded by some RNA viruses of the Potyviridae family. This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.

Gene Full Name: inosine triphosphatase

Gene ID: 3704

UniProt: Q9BY32