IMPA1 antibody (AA 1-277) (HRP)

Catalog No. ABIN7999807

The HRP-conjugated Rabbit Polyclonal anti-IMPA1 antibody (ABIN7999807) specifically detects IMPA1 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for IMPA1 antibody (AA 1-277) (HRP) (ABIN7999807)

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IMPA1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-IMPA1 Antibody (HRP)

Binding Specificity: AA 1-277

Purpose: Anti-IMPA1 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human IMPA1 shares 86.6%,85.1% amino acid (aa) sequence identity with mouse,rat IMPA1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human IMPA1 recombinant protein (Position: M1-D277). Human IMPA1 shares 86.6% and 85.1% amino acid (aa) sequence identity with mouse and rat IMPA1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IMPA1

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Alternative Name: IMPA1

Background:

Background: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Gene Full Name: inositol monophosphatase 1

Gene ID: 3612

UniProt: P29218