IRF4 antibody (AA 163-419) (Fluoro594)

Catalog No. ABIN8001258

The Rabbit Polyclonal anti-IRF4 antibody is suitable to detect IRF4 in samples from Human. It has been validated for FACS.

Quick Overview for IRF4 antibody (AA 163-419) (Fluoro594) (ABIN8001258)

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF4 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-IRF4 Antibody (Fluoro594)

Binding Specificity: AA 163-419

Purpose: Anti-MUM1/IRF4 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MUM1/IRF4 recombinant protein (Position: A163-Q419). Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Alternative Name: IRF4

Background:

Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

Gene Full Name: interferon regulatory factor 4

Gene ID: 3662

UniProt: Q15306

Pathways: Chromatin Binding