IFT74 antibody (AA 1-375) (Fluoro594)

Catalog No. ABIN8003139

The Rabbit Polyclonal anti-IFT74 antibody is suitable to detect IFT74 in samples from Human, Rat, Mouse and Monkey. It has been validated for FACS.

Quick Overview for IFT74 antibody (AA 1-375) (Fluoro594) (ABIN8003139)

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFT74 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-IFT74 Antibody (Fluoro594)

Binding Specificity: AA 1-375

Purpose: Anti-IFT74 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PELI3 shares 90.1% amino acid (aa) sequence identity with mouse PELI3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PELI3 recombinant protein (Position: M1-R375). Human PELI3 shares 90.1% amino acid (aa) sequence identity with mouse PELI3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IFT74

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Alternative Name: IFT74

Background:

Background: Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene. This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.

Gene Full Name: intraflagellar transport 74

Gene ID: 80173

UniProt: Q96LB3

Pathways: Hedgehog Signaling, Chromatin Binding