Involucrin antibody (C-Term) (HRP)

Catalog No. ABIN8003185

The HRP-conjugated Rabbit Polyclonal anti-Involucrin antibody (ABIN8003185) specifically detects Involucrin in IHC, WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Involucrin antibody (C-Term) (HRP) (ABIN8003185)

Target: Involucrin (IVL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Involucrin antibody is conjugated to HRP

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Product Details anti-Involucrin Antibody (HRP)

Binding Specificity: C-Term

Purpose: Anti-Involucrin/IVL Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Involucrin.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Involucrin

Target: Involucrin (IVL)

Alternative Name: IVL

Background:

Background: Involucrin?is a?protein?component of human skin and in humans is encoded by the?IVL?gene. It is a highly reactive, soluble,?transglutaminase?substrate?protein?present in?keratinocytes?of?epidermisand other?stratified squamous epithelia. It first appears in the?cell?cytosol, but ultimately becomes cross-linked to?membrane proteins?by transglutaminase thus helping in the formation of an insoluble envelope beneath theplasma membrane?functioning as a?glutamyl?donor during assembly of the cornified envelope. Additionally, Involucrin is synthesised in the?stratum spinosum?and cross linked in the?stratum granulosum?by thetransglutaminase?enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.

Gene Full Name: involucrin

Gene ID: 3713

UniProt: P07476