Involucrin antibody (C-Term)

Catalog No. ABIN8003189

This Rabbit Polyclonal antibody specifically detects Involucrin in WB. It exhibits reactivity toward Human.

Quick Overview for Involucrin antibody (C-Term) (ABIN8003189)

Target: Involucrin (IVL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Involucrin antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-Involucrin Antibody

Binding Specificity: C-Term

Purpose: Anti-Involucrin/IVL Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Involucrin/IVL Antibody. Tested in WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Involucrin.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Involucrin

Target: Involucrin (IVL)

Alternative Name: IVL

Background:

Background: Involucrin?is a?protein?component of human skin and in humans is encoded by the?IVL?gene. It is a highly reactive, soluble,?transglutaminase?substrate?protein?present in?keratinocytes?of?epidermisand other?stratified squamous epithelia. It first appears in the?cell?cytosol, but ultimately becomes cross-linked to?membrane proteins?by transglutaminase thus helping in the formation of an insoluble envelope beneath theplasma membrane?functioning as a?glutamyl?donor during assembly of the cornified envelope. Additionally, Involucrin is synthesised in the?stratum spinosum?and cross linked in the?stratum granulosum?by thetransglutaminase?enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.

Gene Full Name: involucrin

Molecular Weight: 120 kDa

Gene ID: 3713

UniProt: P07476