ISL1 antibody (AA 118-161) (Fluoro647)

Catalog No. ABIN8003331

The Rabbit Polyclonal anti-ISL1 antibody is suitable to detect ISL1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for ISL1 antibody (AA 118-161) (Fluoro647) (ABIN8003331)

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISL1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-ISL1 Antibody (Fluoro647)

Binding Specificity: AA 118-161

Purpose: Anti-Islet 1/ISL1 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human ISL1 shares 100% amino acid (aa) sequence identity with both mouse,rat ISL1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Islet 1/ISL1 recombinant protein (Position: D118-E161). Human ISL1 shares 100% amino acid (aa) sequence identity with both mouse and rat ISL1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ISL1

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Alternative Name: ISL1

Background:

Background: Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

Gene Full Name: ISL LIM homeobox 1

Gene ID: 3670

UniProt: P61371

Pathways: Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding