ISOC2 antibody (AA 1-205) (APC)

Catalog No. ABIN8003373

The Rabbit Polyclonal anti-ISOC2 antibody is suitable to detect ISOC2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for ISOC2 antibody (AA 1-205) (APC) (ABIN8003373)

Target: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISOC2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-ISOC2 Antibody (APC)

Binding Specificity: AA 1-205

Purpose: Anti-ISOC2 Antibody APC Conjugated

Predicted Reactivity: Human ISOC2 shares 84.2%,75% amino acid (aa) sequence identity with mouse,rat ISOC2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ISOC2 recombinant protein (Position: M1-H205). Human ISOC2 shares 84.2% and 75% amino acid (aa) sequence identity with mouse and rat ISOC2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ISOC2

Target: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Alternative Name: ISOC2

Background:

Background: ISOC2 (isochorismatase domain-containing protein 2) is a 205 amino acid protein belonging to the isochorismatase family. Isochorismatase is an enzyme that catalyzes the chemical reaction of isochorismate and water to 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate. Localized to mitochondrion and cytoplasm, ISOC2 interacts with CDKN2A and localizes to the nucleus in the presence of it. ISOC2 is ubiquitously expressed, with highest levels found in uterus, stomach and urinary tract system. Over-expressed ISOC2 inhibits the expression of CDKN2A, suggesting that this novel gene may play a role during tumor development by interacting with CDKN2A. Three isoforms are produced by alternative splicing events.

Gene Full Name: isochorismatase domain containing 2

Gene ID: 79763

UniProt: Q96AB3