ISOC2 antibody (AA 1-205)

Catalog No. ABIN8003376

The Rabbit Polyclonal anti-ISOC2 antibody is suitable to detect ISOC2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, ICC and IF.

Quick Overview for ISOC2 antibody (AA 1-205) (ABIN8003376)

Target: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISOC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-ISOC2 Antibody

Binding Specificity: AA 1-205

Purpose: Anti-ISOC2 Antibody

Predicted Reactivity: Human ISOC2 shares 84.2%,75% amino acid (aa) sequence identity with mouse,rat ISOC2,respectively.

Characteristics: Anti-ISOC2 Antibody. Tested in WB, IF, ICC, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ISOC2 recombinant protein (Position: M1-H205). Human ISOC2 shares 84.2% and 75% amino acid (aa) sequence identity with mouse and rat ISOC2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ISOC2

Target: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Alternative Name: ISOC2

Background:

Background: ISOC2 (isochorismatase domain-containing protein 2) is a 205 amino acid protein belonging to the isochorismatase family. Isochorismatase is an enzyme that catalyzes the chemical reaction of isochorismate and water to 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate. Localized to mitochondrion and cytoplasm, ISOC2 interacts with CDKN2A and localizes to the nucleus in the presence of it. ISOC2 is ubiquitously expressed, with highest levels found in uterus, stomach and urinary tract system. Over-expressed ISOC2 inhibits the expression of CDKN2A, suggesting that this novel gene may play a role during tumor development by interacting with CDKN2A. Three isoforms are produced by alternative splicing events.

Gene Full Name: isochorismatase domain containing 2

Molecular Weight: 22 kDa

Gene ID: 79763

UniProt: Q96AB3