Kallikrein 5 antibody (C-Term) (Fluoro550)

Catalog No. ABIN8003886

The Rabbit Polyclonal anti-Kallikrein 5 antibody is suitable to detect Kallikrein 5 in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for Kallikrein 5 antibody (C-Term) (Fluoro550) (ABIN8003886)

Target: Kallikrein 5 (KLK5)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kallikrein 5 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Kallikrein 5 Antibody (Fluoro550)

Binding Specificity: C-Term

Purpose: Anti-Kallikrein 5/KLK5 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat sequence by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 5, different from the related rat sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Kallikrein 5

Target: Kallikrein 5 (KLK5)

Alternative Name: KLK5

Background:

Background: KLK5 (Kallikrein-related peptidase 5), formerly known as stratum corneum tryptic enzyme (SCTE) or KLKL2, is a serine protease expressed in the epidermis. The KLK5 gene is one of the fifteen kallikrein subfamily members which is located on 19q13.41. KLK5 has been suggested to regulate cell shedding in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. The KLK5 gene contains 5 coding exons spanning 9.3. KLK5 expression is upregulated in a breast cancer cell line in the presence of estrogens and progestins and is associated with more aggressive forms of epithelial ovarian carcinoma.

Gene Full Name: kallikrein related-peptidase 5

Sequence Similarities: Belongs to the integrin beta chain family.

Gene ID: 68668

UniProt: Q9D140

Pathways: Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling