KPNB1 antibody (AA 8-876) (APC)

Catalog No. ABIN8003978

This Mouse Monoclonal antibody specifically detects KPNB1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KPNB1 antibody (AA 8-876) (APC) (ABIN8003978)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KPNB1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 3I11F2

Product Details anti-KPNB1 Antibody (APC)

Binding Specificity: AA 8-876

Purpose: Anti-KPNB1 Antibody (monoclonal, 3I11F2) APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human KPNB1 recombinant protein (Position: E8-A876).

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Alternative Name: KPNB1

Background:

Background: Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: karyopherin subunit beta 1

Gene ID: 3837

UniProt: Q14974

Pathways: Protein targeting to Nucleus