Cytokeratin 1 antibody (AA 223-439) (HRP)

Catalog No. ABIN8004087

The Rabbit Polyclonal anti-Cytokeratin 1 antibody is suitable to detect Cytokeratin 1 in samples from Mouse. It has been validated for IHC, WB and ELISA.

Quick Overview for Cytokeratin 1 antibody (AA 223-439) (HRP) (ABIN8004087)

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytokeratin 1 antibody is conjugated to HRP

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Product Details anti-Cytokeratin 1 Antibody (HRP)

Binding Specificity: AA 223-439

Purpose: Anti-Cytokeratin 1/Krt1 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Cytokeratin 1/Krt1 recombinant protein (Position: L223-Q439).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Cytokeratin 1

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Alternative Name: Krt1

Background:

Background: Keratin 1 (KRT1), also known as Cytokeratin 1, or Keratin, type II cytoskeletal 1, is a member of the keratin family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants ofbullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. And this type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Full Name: keratin 1

Gene ID: 16678

UniProt: P04104