KIF15 antibody (AA 1201-1388) (Biotin)

Catalog No. ABIN8004433

The Biotin-conjugated Rabbit Polyclonal anti-KIF15 antibody (ABIN8004433) specifically detects KIF15 in ELISA, WB and IHC. The antibody is reactive with Human and Rat samples.

Quick Overview for KIF15 antibody (AA 1201-1388) (Biotin) (ABIN8004433)

Target: KIF15 (Kinesin Family Member 15 (KIF15))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF15 antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KIF15 Antibody (Biotin)

Binding Specificity: AA 1201-1388

Purpose: Anti-KIF15 Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human KIF15 recombinant protein (Position: M1201-S1388).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for KIF15

Target: KIF15 (Kinesin Family Member 15 (KIF15))

Alternative Name: KIF15

Background:

Background: Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene. It is mapped to 3p21.31. This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons. KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth. KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11. KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner. Hence, inhibition of KIF15 function will be a vital therapeutic approach in cancer chemotherapy.

Gene Full Name: kinesin family member 15

Gene ID: 56992

UniProt: Q9NS87