KLC1 antibody (AA 1-537) (APC)

Catalog No. ABIN8004561

The Mouse Monoclonal anti-KLC1 antibody is suitable to detect KLC1 in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for KLC1 antibody (AA 1-537) (APC) (ABIN8004561)

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLC1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 4F2D7

Product Details anti-KLC1 Antibody (APC)

Binding Specificity: AA 1-537

Purpose: Anti-KLC1 Antibody (monoclonal, 4F2D7) APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human KLC1 recombinant protein (Position: M1-D537).

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for KLC1

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Alternative Name: KLC1

Background:

Background: Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos, however, the full-length nature and/or biological validity of most of these variants have not been determined.

Gene Full Name: kinesin light chain 1

Gene ID: 3831

UniProt: Q07866

Pathways: Ribonucleoprotein Complex Subunit Organization