KLF6 antibody (AA 38-205) (Fluoro594)

Catalog No. ABIN8004768

The Rabbit Polyclonal anti-KLF6 antibody is suitable to detect KLF6 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for KLF6 antibody (AA 38-205) (Fluoro594) (ABIN8004768)

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF6 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-KLF6 Antibody (Fluoro594)

Binding Specificity: AA 38-205

Purpose: Anti-KLF6 Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human KLF6 shares 92%,90% amino acid (aa) sequences identity with mouse,rat KLF6,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human KLF6 recombinant protein (Position: E38-N205). Human KLF6 shares 92% and 90% amino acid (aa) sequences identity with mouse and rat KLF6, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Alternative Name: KLF6

Background:

Background: Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene which is located on 10p15.1. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.

Gene Full Name: KLF transcription factor 6

Sequence Similarities: Belongs to the krueppel C2H2-type zinc-finger protein family.

Gene ID: 1316

UniProt: Q99612