L1CAM antibody (AA 223-1218) (Fluoro647)

Catalog No. ABIN8004861

The Rabbit Polyclonal anti-L1CAM antibody is suitable to detect L1CAM in samples from Human and Rat. It has been validated for FACS.

Quick Overview for L1CAM antibody (AA 223-1218) (Fluoro647) (ABIN8004861)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L1CAM antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-L1CAM Antibody (Fluoro647)

Binding Specificity: AA 223-1218

Purpose: Anti-L1CAM Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human L1CAM recombinant protein (Position: E223-Q1218).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: L1CAM

Background:

Background: L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Gene Full Name: L1 cell adhesion molecule

Gene ID: 3897

UniProt: P32004

Pathways: Synaptic Membrane