Lamin B2 antibody (AA 128-585) (Biotin)

Catalog No. ABIN8005028

This Rabbit Polyclonal antibody specifically detects Lamin B2 in WB, IHC and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for Lamin B2 antibody (AA 128-585) (Biotin) (ABIN8005028)

Target: Lamin B2 (LMNB2)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B2 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Lamin B2 Antibody (Biotin)

Binding Specificity: AA 128-585

Purpose: Anti-Lamin B2/LMNB2 Antibody Biotin Conjugated

Predicted Reactivity: Human LMNB2 shares 81.8% amino acid (aa) sequence identity with mouse LMNB2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Lamin B2/LMNB2 recombinant protein (Position: L128-E585). Human LMNB2 shares 81.8% amino acid (aa) sequence identity with mouse LMNB2.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Lamin B2

Target: Lamin B2 (LMNB2)

Alternative Name: Lamin B2/LMNB2

Background:

Background: Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.

Gene Full Name: lamin B2

Gene ID: 84823

UniProt: Q03252

Pathways: Apoptosis, Caspase Cascade in Apoptosis