Lamin B2 antibody (C-Term) (HRP)

Catalog No. ABIN8005045

The HRP-conjugated Rabbit Polyclonal anti-Lamin B2 antibody (ABIN8005045) specifically detects Lamin B2 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Lamin B2 antibody (C-Term) (HRP) (ABIN8005045)

Target: Lamin B2 (LMNB2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Lamin B2 Antibody (HRP)

Binding Specificity: C-Term

Purpose: Anti-Lamin B2/LMNB2 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related rat,mouse sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B2, identical to the related rat and mouse sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Lamin B2

Target: Lamin B2 (LMNB2)

Alternative Name: LMNB2

Background:

Background: Lamin B2, also called LMNB2, is a protein associated with laminopathies. The LMNB2 gene is mapped to the G-negative subtelomeric band p13.3 of chromosome 19 by in situ hybridization. The LMNB2 gene contains 12 exons. < a href=https://www.bosterbio.com/blog/post/how-to-choose-a-model-organism style=color:#EA8D28>Common model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2, is generated as part of the International Knockout Mouse Consortium program-a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. A highly sensitive procedure about mapping the start site of DNA replication in a 13.7-kb region of human chromosome 19 coding for lamin B2 is developed for the identification of the origin of biional DNA synthesis in single-copy replicons of mammalian cells.

Gene Full Name: lamin B2

Sequence Similarities: Belongs to the intermediate filament family.

Gene ID: 84823

UniProt: Q03252

Pathways: Apoptosis, Caspase Cascade in Apoptosis