LMOD3 antibody (AA 45-558) (Fluoro488)

Catalog No. ABIN8005304

This Rabbit Polyclonal antibody specifically detects LMOD3 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LMOD3 antibody (AA 45-558) (Fluoro488) (ABIN8005304)

Target: LMOD3 (Leiomodin 3 (LMOD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMOD3 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-LMOD3 Antibody (Fluoro488)

Binding Specificity: AA 45-558

Purpose: Anti-LMOD3 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human LMOD3 shares 72.2% amino acid (aa) sequence identity with mouse LMOD3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LMOD3 recombinant protein (Position: D45-E558). Human LMOD3 shares 72.2% amino acid (aa) sequence identity with mouse LMOD3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LMOD3

Target: LMOD3 (Leiomodin 3 (LMOD3))

Alternative Name: LMOD3

Background:

Background: Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene. The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder.

Gene Full Name: leiomodin 3

Gene ID: 56203

UniProt: Q0VAK6