LEMD3 antibody (AA 535-852) (Fluoro647)

Catalog No. ABIN8005322

This Rabbit Polyclonal antibody specifically detects LEMD3 in FACS. It exhibits reactivity toward Human.

Quick Overview for LEMD3 antibody (AA 535-852) (Fluoro647) (ABIN8005322)

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEMD3 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-LEMD3 Antibody (Fluoro647)

Binding Specificity: AA 535-852

Purpose: Anti-LEMD3 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LEMD3 recombinant protein (Position: H535-H852).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LEMD3

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Alternative Name: LEMD3

Background:

Background: LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene[5] and was first identified after it was isolated from the serum of a patient with a collagen vascular disease. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene Full Name: LEM domain containing 3

Gene ID: 23592

UniProt: Q9Y2U8