LIN7C antibody (AA 1-73) (Fluoro647)

Catalog No. ABIN8006194

The Fluoro647-conjugated Rabbit Polyclonal anti-LIN7C antibody (ABIN8006194) specifically detects LIN7C in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for LIN7C antibody (AA 1-73) (Fluoro647) (ABIN8006194)

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN7C antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-LIN7C Antibody (Fluoro647)

Binding Specificity: AA 1-73

Purpose: Anti-LIN7C Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LIN7C recombinant protein (Position: M1-A73).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LIN7C

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Alternative Name: LIN7C

Background:

Background: Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Gene Full Name: lin-7 cell polarity scaffold C

Gene ID: 55327

UniProt: Q9NUP9

Pathways: Synaptic Membrane