LYAR antibody (AA 1-379) (Cy3)

Catalog No. ABIN8006735

This Rabbit Polyclonal antibody specifically detects LYAR in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LYAR antibody (AA 1-379) (Cy3) (ABIN8006735)

Target: LYAR (Ly1 Antibody Reactive (LYAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LYAR antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-LYAR Antibody (Cy3)

Binding Specificity: AA 1-379

Purpose: Anti-LYAR Antibody Cy3 Conjugated

Predicted Reactivity: Human LYAR shares 71.9%,73.7% amino acid (aa) sequence identity with mouse,rat LYAR,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LYAR recombinant protein (Position: M1-K379). Human LYAR shares 71.9% and 73.7% amino acid (aa) sequence identity with mouse and rat LYAR, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LYAR

Target: LYAR (Ly1 Antibody Reactive (LYAR))

Alternative Name: LYAR

Target Type: Antibody

Background:

Background: Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone). LYAR (Ly-1/CD5 antibody reactive clone) is a 45-50 kDa nucleolar protein that was named for the ability of its antibody to cross-react with Ly-1. Its function is unclear, it is known to associate with MYCN and RRP1B, the latter association giving rise to the suggestion that LYAR is involved with RNA metabolism. Human LYAR is 379 amino acids (aa) in length. It contains two C2H2-type Zn finger regions (aa 6-25 and 33-51) followed by one coiled-coil region (aa 175-219) and an NLS (aa 217-222). There are multiple Zn-binding sites and three utilized phosphorylation sites at Ser244, Ser258 and Ser276. Over aa 288-379, human LYAR shares 75 % aa identity with mouse LYAR.

Gene Full Name: Ly1 antibody reactive

Gene ID: 55646

UniProt: Q9NX58