MASP1 antibody (AA 169-580) (FITC)

Catalog No. ABIN8007642

The Rabbit Polyclonal anti-MASP1 antibody is suitable to detect MASP1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for MASP1 antibody (AA 169-580) (FITC) (ABIN8007642)

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-MASP1 Antibody (FITC)

Binding Specificity: AA 169-580

Purpose: Anti-MASP1 Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MASP1 shares 84.5%,83.3% amino acid (aa) sequence identity with mouse,rat MASP1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MASP1 recombinant protein (Position: R169-E580). Human MASP1 shares 84.5% and 83.3% amino acid (aa) sequence identity with mouse and rat MASP1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Alternative Name: MASP1

Background:

Background: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Gene Full Name: MBL associated serine protease 1

Gene ID: 5648

UniProt: P48740

Pathways: Complement System