MMP20 antibody (AA 124-405) (APC)

Catalog No. ABIN8008337

This Rabbit Polyclonal antibody specifically detects MMP20 in FACS. It exhibits reactivity toward Human.

Quick Overview for MMP20 antibody (AA 124-405) (APC) (ABIN8008337)

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP20 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MMP20 Antibody (APC)

Binding Specificity: AA 124-405

Purpose: Anti-MMP20 Antibody APC Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human MMP20 shares 91.5% amino acid (aa) sequence identity with mouse MMP20.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MMP20 recombinant protein (Position: Y124-K405). Human MMP20 shares 91.5% amino acid (aa) sequence identity with mouse MMP20.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MMP20

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Alternative Name: MMP20

Background:

Background: Matrix metalloproteinase-20 (MMP-20) also known as enamel metalloproteinase or enamelysin is an enzyme that in humans is encoded by the MMP20 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.

Gene Full Name: matrix metallopeptidase 20

Gene ID: 9313

UniProt: O60882