MECOM antibody (AA 125-743) (APC)

Catalog No. ABIN8008513

The APC-conjugated Rabbit Polyclonal anti-MECOM antibody (ABIN8008513) specifically detects MECOM in FACS. The antibody is reactive with Human samples.

Quick Overview for MECOM antibody (AA 125-743) (APC) (ABIN8008513)

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MECOM antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MECOM Antibody (APC)

Binding Specificity: AA 125-743

Purpose: Anti-EVI1/MECOM Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human EVI1/MECOM recombinant protein (Position: E125-D743).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MECOM

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Alternative Name: MECOM

Background:

Background: MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene Full Name: MDS1 and EVI1 complex locus

Gene ID: 2122

UniProt: Q03112