MED7 antibody (AA 1-233) (Fluoro647)

Catalog No. ABIN8008702

The Fluoro647-conjugated Rabbit Polyclonal anti-MED7 antibody (ABIN8008702) specifically detects MED7 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MED7 antibody (AA 1-233) (Fluoro647) (ABIN8008702)

Target: MED7 (Mediator Complex Subunit 7 (MED7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED7 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-MED7 Antibody (Fluoro647)

Binding Specificity: AA 1-233

Purpose: Anti-MED7 Antibody Fluoro647 Conjugated

Predicted Reactivity: Human MED7 shares 97% amino acid (aa) sequence identity with mouse MED7.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MED7 recombinant protein (Position: M1-P233). Human MED7 shares 97% amino acid (aa) sequence identity with mouse MED7.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MED7

Target: MED7 (Mediator Complex Subunit 7 (MED7))

Alternative Name: MED7

Background:

Background: Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.

Gene Full Name: mediator complex subunit 7

Gene ID: 9443

UniProt: O43513

Pathways: Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha