MATK antibody (AA 18-298) (Cy3)

Catalog No. ABIN8008782

The Rabbit Polyclonal anti-MATK antibody is suitable to detect MATK in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for MATK antibody (AA 18-298) (Cy3) (ABIN8008782)

Target: MATK (Megakaryocyte-Associated tyrosine Kinase (MATK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MATK antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-MATK Antibody (Cy3)

Binding Specificity: AA 18-298

Purpose: Anti-MATK Antibody Cy3 Conjugated

Predicted Reactivity: Human MATK shares 88.5%,91.4% amino acid (aa) sequence identity with mouse,rat MATK,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MATK recombinant protein (Position: S18-Q298). Human MATK shares 88.5% and 91.4% amino acid (aa) sequence identity with mouse and rat MATK, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MATK

Target: MATK (Megakaryocyte-Associated tyrosine Kinase (MATK))

Alternative Name: MATK

Background:

Background: Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene. The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene Full Name: megakaryocyte-associated tyrosine kinase

Gene ID: 4145

UniProt: P42679