Melanophilin antibody (AA 61-523) (Biotin)

Catalog No. ABIN8008957

The Biotin-conjugated Rabbit Polyclonal anti-Melanophilin antibody (ABIN8008957) specifically detects Melanophilin in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for Melanophilin antibody (AA 61-523) (Biotin) (ABIN8008957)

Target: Melanophilin (MLPH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Melanophilin antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Melanophilin Antibody (Biotin)

Binding Specificity: AA 61-523

Purpose: Anti-MLPH Antibody Biotin Conjugated

Predicted Reactivity: Human Melanophilin,MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin,MLPH.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Melanophilin/MLPH recombinant protein (Position: E61-L523). Human Melanophilin/MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin/MLPH.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Melanophilin

Target: Melanophilin (MLPH)

Alternative Name: MLPH

Background:

Background: Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: melanophilin

Gene ID: 79083

UniProt: Q9BV36