Melanophilin antibody (AA 61-523)

Catalog No. ABIN8008967

This Rabbit Polyclonal antibody specifically detects Melanophilin in WB, ELISA, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for Melanophilin antibody (AA 61-523) (ABIN8008967)

Target: Melanophilin (MLPH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Melanophilin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Grade: Carrier-free

Product Details anti-Melanophilin Antibody

Binding Specificity: AA 61-523

Purpose: Anti-MLPH Antibody

Predicted Reactivity: Human Melanophilin,MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin,MLPH.

Characteristics: Anti-MLPH Antibody. Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Melanophilin/MLPH recombinant protein (Position: E61-L523). Human Melanophilin/MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin/MLPH.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Melanophilin

Target: Melanophilin (MLPH)

Alternative Name: MLPH

Background:

Background: Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: melanophilin

Molecular Weight: 85 kDa

Gene ID: 79083

UniProt: Q9BV36