MTA2 antibody (AA 1-668) (HRP)

Catalog No. ABIN8009392

The HRP-conjugated Rabbit Polyclonal anti-MTA2 antibody (ABIN8009392) specifically detects MTA2 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MTA2 antibody (AA 1-668) (HRP) (ABIN8009392)

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-MTA2 Antibody (HRP)

Binding Specificity: AA 1-668

Purpose: Anti-MTA2/PID Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MTA2/PID recombinant protein (Position: M1-D668).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MTA2

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Alternative Name: MTA2

Background:

Background: Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene. It is mapped to 11q12.3. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either ly or inly in transcriptional regulation. Their in effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Gene Full Name: metastasis associated 1 family member 2

Gene ID: 9219

UniProt: O94776

Pathways: Chromatin Binding