MBD2 antibody (AA 159-411) (FITC)

Catalog No. ABIN8009578

The FITC-conjugated Rabbit Polyclonal anti-MBD2 antibody (ABIN8009578) specifically detects MBD2 in FACS. The antibody is reactive with Human samples.

Quick Overview for MBD2 antibody (AA 159-411) (FITC) (ABIN8009578)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD2 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-MBD2 Antibody (FITC)

Binding Specificity: AA 159-411

Purpose: Anti-MBD2 Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MBD2 shares 98% amino acid (aa) sequence identity with mouse MBD2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MBD2 recombinant protein (Position: W159-A411). Human MBD2 shares 98% amino acid (aa) sequence identity with mouse MBD2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2

Background:

Background: Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. It is mapped to 18q21.2. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Gene Full Name: methyl-CpG binding domain protein 2

Sequence Similarities: Contains 1 MBD (methyl-CpG-binding) domain.

Gene ID: 8932

UniProt: Q9UBB5

Pathways: Chromatin Binding