MVK antibody (AA 13-394) (PE)

Catalog No. ABIN8009878

The PE-conjugated Rabbit Polyclonal anti-MVK antibody (ABIN8009878) specifically detects MVK in FACS. The antibody is reactive with Human samples.

Quick Overview for MVK antibody (AA 13-394) (PE) (ABIN8009878)

Target: MVK (Mevalonate Kinase (MVK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MVK antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-MVK Antibody (PE)

Binding Specificity: AA 13-394

Purpose: Anti-MVK Antibody PE Conjugated

Predicted Reactivity: Human MVK shares 80.8%,81.4% amino acid (aa) sequence identity with mouse,rat MVK,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MVK recombinant protein (Position: K13-D394). Human MVK shares 80.8% and 81.4% amino acid (aa) sequence identity with mouse and rat MVK, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MVK

Target: MVK (Mevalonate Kinase (MVK))

Alternative Name: MVK

Background:

Background: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants.

Gene Full Name: mevalonate kinase

Gene ID: 4598

UniProt: Q03426