MID1 antibody (AA 226-278) (Fluoro550)

Catalog No. ABIN8010193

The Fluoro550-conjugated Rabbit Polyclonal anti-MID1 antibody (ABIN8010193) specifically detects MID1 in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for MID1 antibody (AA 226-278) (Fluoro550) (ABIN8010193)

Target: MID1 (Midline 1 (MID1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MID1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-MID1 Antibody (Fluoro550)

Binding Specificity: AA 226-278

Purpose: Anti-MID1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MID1 recombinant protein (Position: N226-Q278).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MID1

Target: MID1 (Midline 1 (MID1))

Alternative Name: MID1

Background:

Background: Midline-1 is a protein found in humans that is encoded by the MID1 gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities.

Gene Full Name: midline 1

Gene ID: 4281

UniProt: O15344