MFN2 antibody (AA 601-757) (APC)

Catalog No. ABIN8010868

The APC-conjugated Rabbit Polyclonal anti-MFN2 antibody (ABIN8010868) specifically detects MFN2 in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MFN2 antibody (AA 601-757) (APC) (ABIN8010868)

Target: MFN2 (Mitofusin 2 (MFN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFN2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MFN2 Antibody (APC)

Binding Specificity: AA 601-757

Purpose: Anti-Mitofusin 2/MFN2 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Mitofusin 2 shares 96%,95% amino acid (aa) sequence identity with mouse,rat Mitofusin 2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Mitofusin 2 recombinant protein (Position: V601-R757). Human Mitofusin 2 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat Mitofusin 2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: MFN2

Background:

Background: Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. This gene is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. It has been found that MFN2 triggers mitochondrial energization, at least in part, by regulating OXPHOS expression through signals that are independent of its role as a mitochondrial fusion protein. And it contributes to the maintenance and operation of the mitochondrial network. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.

Gene Full Name: mitofusin 2

Sequence Similarities: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.

Gene ID: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development