MMS19 antibody (AA 239-998) (Fluoro488)

Catalog No. ABIN8011490

This Rabbit Polyclonal antibody specifically detects MMS19 in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for MMS19 antibody (AA 239-998) (Fluoro488) (ABIN8011490)

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMS19 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MMS19 Antibody (Fluoro488)

Binding Specificity: AA 239-998

Purpose: Anti-MMS19 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MMS19 recombinant protein (Position: E239-R998).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MMS19

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Alternative Name: MMS19

Background:

Background: MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene. MMS19 (MMS19 nucleotide excision repair homolog), also known as MET18, is a 1,030 amino acid nuclear protein containing seven HEAT repeats that belongs to the MET18/MMS19 family. Via its interactions with TFIIH p80 and TFIIH p89 helicases, MMS19 plays a role in nucleotide excision repair (NER) and RNA polymerase II (Pol II) transcription. MMS19 may also function as a transcriptional coactivator of estrogen receptor. While ubiquitously expressed, highest levels of MMS19 have been found in testis. At least five distinct MMS19 protein isoforms exist, which are produced by alternative splicing events.

Gene Full Name: MMS19 cytosolic iron-sulfur assembly component

Gene ID: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding