MBNL1 antibody (AA 89-388) (Fluoro488)

Catalog No. ABIN8012150

This Rabbit Polyclonal antibody specifically detects MBNL1 in FACS. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for MBNL1 antibody (AA 89-388) (Fluoro488) (ABIN8012150)

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MBNL1 Antibody (Fluoro488)

Binding Specificity: AA 89-388

Purpose: Anti-MBNL1 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MBNL1 recombinant protein (Position: Q89-M388).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MBNL1

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Alternative Name: MBNL1

Background:

Background: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

Gene Full Name: muscleblind like splicing regulator 1

Gene ID: 4154

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization