MPZ antibody (AA 30-153) (APC)

Catalog No. ABIN8012397

The Rabbit Polyclonal anti-MPZ antibody is suitable to detect MPZ in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for MPZ antibody (AA 30-153) (APC) (ABIN8012397)

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPZ antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MPZ Antibody (APC)

Binding Specificity: AA 30-153

Purpose: Anti-Myelin Protein Zero/MPZ Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Myelin Protein Zero recombinant protein (Position: I30-R153).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: MPZ

Background:

Background: Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Gene Full Name: myelin protein zero

Gene ID: 4359

UniProt: P25189