NANS antibody (AA 1-341) (FITC)

Catalog No. ABIN8013012

The Rabbit Polyclonal anti-NANS antibody is suitable to detect NANS in samples from Human and Rat. It has been validated for FACS.

Quick Overview for NANS antibody (AA 1-341) (FITC) (ABIN8013012)

Target: NANS (N-Acetylneuraminic Acid Synthase (NANS))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NANS antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-NANS Antibody (FITC)

Binding Specificity: AA 1-341

Purpose: Anti-NANS Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human NANS shares 96.2% amino acid (aa) sequence identity with mouse NANS.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NANS recombinant protein (Position: M1-E341). Human NANS shares 96.2% amino acid (aa) sequence identity with mouse NANS.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NANS

Target: NANS (N-Acetylneuraminic Acid Synthase (NANS))

Alternative Name: NANS

Background:

Background: Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively, however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

Gene Full Name: N-acetylneuraminate synthase

Gene ID: 54187

UniProt: Q9NR45