NBR1 antibody (AA 1-665) (Cy3)

Catalog No. ABIN8014197

The Rabbit Polyclonal anti-NBR1 antibody is suitable to detect NBR1 in samples from Human and Monkey. It has been validated for FACS.

Quick Overview for NBR1 antibody (AA 1-665) (Cy3) (ABIN8014197)

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NBR1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-NBR1 Antibody (Cy3)

Binding Specificity: AA 1-665

Purpose: Anti-NBR1 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NBR1 recombinant protein (Position: M1-H665).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Alternative Name: NBR1

Background:

Background: Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: NBR1 autophagy cargo receptor

Gene ID: 4077

UniProt: Q14596

Pathways: Autophagy